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med's go on Instagram: "Alpha-2 adrenergic receptors (especially the α2A subtype) are located presynaptically on noradrenergic neuron terminals in both the central and peripheral nervous systems. When norepinephrine binds to these autoreceptors, they couple to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP, and hyperpolarizing the neuron via opening of potassium channels and closure of voltage-gated calcium channels. The net effect is strong negative feedback inhibition of further no
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