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Is Sperm also responsible ? Sperm DNA damage (DNA fragmentation) affects both fertility and pregnancy outcomes. • It can cause infertility, poor embryo quality, and IVF/ICSI failure even when semen analysis is normal. • It is linked to recurrent miscarriage, failed implantation, preeclampsia, preterm birth, and low birth weight. • Common causes: oxidative stress, smoking, varicocele, infections, heat, toxins, and advanced paternal age. • A DNA fragmentation index (DFI) >25–30% is usually conside
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