Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

Alzforum webpages for each DIAN-TU-eligible variant now state “DIAN-TU eligibility: Yes” near the top of the page and an explanation under the Pathogenicity section (see, for example, PSEN1 M146V ).

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

See α-Synuclein. Candidate tracer SY08 detects α-synuclein deposits in the brainstem (right) and parietal cortex (left) of ...

A new consortium aims to speed the pace of basic science discovery in AD and related diseases. A future AI assistant is to ...

Vaccine Step Down. A person’s probability of developing dementia over seven years increased with age. It was higher in the ...

Positive signals in tau PET scans and p-tau217 assays both suggest cognitive decline, but which performs better? Neither, according to a study published March 28 in Nature Aging—at least in people who ...