A research group led by Kazunobu Sawamoto, a professor at Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences and National Institute for Physiological Sciences, and ...

Researchers at Kyushu University have uncovered the mechanisms of a fundamental yet critically under-looked phase in brain development: synaptic pruning. How neurons connect and remodel themselves is ...

In the Alzheimer’s disease brain, synaptic loss correlates with cognitive decline, and is considered a sign of disease progression. But is synaptic loss always bad? Provocative new data from several ...

The brain is plastic throughout life, but never more so than from birth to young adulthood. It increases its volume by developing dendrites and axons that connect neurons in to each other, forming new ...

A multidisciplinary team of scientists has discovered the mechanism that controls synaptic pruning of new neurons in the adult brain. The team discovered that microglial cells control the number of ...

Insufficient microglial phagocytosis of amyloid-β (Aβ) and/or excessive phagocytosis of synapses and neurons might underly Alzheimer disease (AD) pathology. Most of the known genetic risk for AD is ...

In the last five years, neuronal pentraxins have emerged as potential markers of synaptic loss. In the case of NPTX2, researchers may now be able to explain why. In the March 29 Science Translational ...

Over the past two decades it has become clear that the complement cascade — best known for its roles in innate immunity and in the clearance of pathogens and immune complexes — has distinct functions ...

Researchers have shown in mice how immune cells in the brain target and remove unused connections between brain cells during normal development. This research, supported by the National Institutes of ...

An analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The ...

The first analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The ...