Electrical deep brain stimulation (DBS) is a well-established method for treating disordered movement in Parkinson's disease. However, implanting electrodes in a person's brain is an invasive and ...

Researchers have developed an animal model that reproduces motor dysfunction and cerebellar neurodegeneration similar to that in spinocerebellar ataxia (SCA) by inhibiting chaperone-mediated autophagy ...

Biomedical engineers at Duke University have used deep brain stimulation based on light to treat motor dysfunction in an animal model of Parkinson's disease. Succeeding where earlier attempts have ...

Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical similarities but have been largely viewed as genetically distinct. However, ...

Niigata, Japan – our movements are controlled by multiple neural pathways that connect the brain and spinal cord. In particular, neurons in the cerebral cortex send commands to the motor neurons in ...

Parkinson’s disease is a progressive disorder of later life, defined clinically by motor features (asymmetric bradykinesia, rigidity, tremor, and imbalance) and pathologically by neuronal degeneration ...

—Patients with greater cognitive dysfunction had a more pronounced change in walking performance during dual-task walking, according to this study. Cognitive-motor dual-tasking, such as simultaneously ...

In patients with ALS, the motor dysfunction symptoms usually appear in one part of the body, such as the limbs, and then progress to others. This further suggests that degeneration starts in one type ...