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Scientists have grown human brain tissue to fill most of a mouse’s cortex, creating a new model for studying brain disease and neural circuits.

The animals may help reveal the causes of brain disease in people and point the way to treatments. But researchers already are calling for new ethical guidelines.

Neuroscientists have made a major advance in modeling the human brain in mice, offering a new way to study conditions like cerebral palsy. Ethicists ask if it changes how these mice should be treated.