Three people have been killed in Israel, according to officials and local media, with both sides saying the strikes will continue.

Israel's widespread airstrikes on Iran effectively damaged the country's nuclear and ballistic missile programs, which officials said was a primary goal. The strikes hit over 100 targets, including Iran's air defense systems,

An aggressive counterattack risks escalation. But giving in to U.S. and Israeli demands is an unlikely alternative.

Israel launched “preemptive” strikes early Friday across Iran, amid growing regional tensions and concerns about Iran’s nuclear capabilities.

Israel’s attack on Iran was long in the making – the result of years of meticulous planning by Israel and days of high-stakes talks between Tel Aviv and Washington, officials told CNN.

Shapiro served as Deputy Assistant Secretary of Defense for the Middle East until January—charged with, among other things, considering scenarios in which tensions between Israel and Iran escalated into all-out war and preparing U.

In response to Israel’s attack, Iran fired back with more than 100 drones. NBC News’ Chief International Correspondent Keir Simmons reports more. Former NATO Supreme Allied Commander retired Gen. Wesley Clark and Senior Fellow at the Carnegie Endowment for International Peace Aaron David Miller join Ana Cabrera to examine the possibility of further attacks.

Israel’s ongoing attacks on Iranian nuclear sites, generals, and scientists killed 78 people and wounded more than 320 on Friday, Iran’s ambassador told the U.N. Security Council, but he said “the overwhelming majority” of victims were civilians. Israel described the new wave of hostilities as the beginning of “Operation Rising Lion.”

Sirens sounded in Israel as Iran launched dozens of ballistic missiles in retaliation for Israel's strikes on its nuclear facilities.

"This confrontation will not end with last night's limited actions and Iran's strikes will continue, and this action will be very painful and regrettable for the aggressors," Fars reported, citing senior military officials.