Treating HIV involves taking antiretroviral medications. Integrase inhibitors, also known as integrase strand transfer inhibitors, are one of the seven classes of antiretroviral drugs. All ...

Switching patients with HIV from a protease inhibitor–based antiretroviral therapy regimen to an integrase inhibitor–based regimen can be performed safely, with maintenance of high levels of virologic ...

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Human immunodeficiency virus (HIV) infection has been transformed over the past two decades from a fatal to a chronic disease, because of combination antiretroviral therapy — a medical triumph. 1 ...

HIV-1 integrase is a rational target for anti-HIV therapy, and the feasibility and efficacy of integrase inhibitors in animal models has been recently demonstrated. Integrase catalyses the insertion ...

On the left is integrase in its “intasome” structure of four identical four-part complexes (pink) that connect to create one 16-part complex that locks around viral DNA (blue). On the right is ...

The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain. While symptoms can now be better managed with lifelong treatment, there is ...

With Gift Aid, your generous donation of £10 would be worth £12.50 at no extra cost to you. Yes, I want to Gift Aid any donations made to NAM now, in the future and in the past four years I am a UK ...

A panelist discusses how the new doravirine and islatravir combination offers an alternative to integrase inhibitor-based therapies, particularly useful for patients with integrase inhibitor ...

People with human immunodeficiency virus (HIV) are living longer thanks to treatments like antiretroviral therapy, or ART. That’s a medication that lowers the amount of HIV in your body and keeps your ...