ESPN announced a major change for the Week 16 showdown between the San Francisco 49ers and Indianapolis Colts.

The 49ers are fighting for their spot in the NFC playoffs this season. Here's where they stand heading into Week 14 of the ...

Most Wednesdays, ESPN P.R. posts a tweet boasting about the audience generated by the NFL game televised two nights earlier.

Christian McCaffrey is making NFL history for the San Francisco 49ers with 1,655 scrimmage yards and top RB receptions ...

Sanders is starting in Week 13 against the San Francisco 49ers, and Garrett gets to go up against Brock Purdy and a shaky ...

The San Francisco 49ers are going to need an X-factor to step up and change the way the team is viewed if they want to make a ...

After the 49ers’ dominant 20-9 home win over the Panthers, San Francisco receiver Jauan Jennings got into a heated ...

Broadcast and streaming information for the San Francisco 49ers Week 12 matchup against the Carolina Panthers at Levi's® Stadium.

After Brandon Aiyuk's guarantees for next season have been voided, Jeremy Fowler reports that the saga is "far from over" for ...

Levi's Stadium in Santa Clara, California, will be the site of Super Bowl LX in February. It's also the stage for the latest edition of ESPN's "Monday Night Football." Fresh off a franchise-record ...

Game summary of the San Francisco 49ers vs. Tampa Bay Buccaneers NFL game, final score 24-17, from November 18, 1984 on ESPN.