The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
The pumping action of the calcium pump protein—an intricate molecular machine with several moving parts that helps control muscle contraction—has been detailed with exquisite precision by RIKEN ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
Muscle function depends on the precise movement of calcium ions between cytosolic and intracellular stores. At rest, cytosolic Ca2+ is maintained at low nanomolar ...
A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...
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