Hsp90 is an abundant, highly conserved molecular chaperone that is essential in eukaryotes. It regulates a wide range of client proteins. Hsp90 is a drug target for anticancer therapies and is also ...
Interactions between proteins and ligands, including interactions between proteins and other substances such as nucleic acids and ATP, play crucial roles in the activities of organisms. ATP plays ...
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Researchers decode tertiary structure of DNA aptamer–ATP complex and improve binding affinity
DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further ...
A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...
MDR3 defects are involved in the development of PFIC3, LPAC, ICP, and DILI. Sterolin 1/2 are cotransporters that transport plant sterols and can lead to sitosterolemia if mutated. MRP2 is responsible ...
A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can ...
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